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RethinkALZ and RefocusALZ Clinical Research Studies
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CLINICAL RESEARCH TO HELP
ADVANCE THE TREATMENT
OF ALZHEIMER’S

RethinkALZ and RefocusALZ are the names of two new clinical trials for Alzheimer’s disease. The purpose of these trials is to determine if a new, twice-a-day, oral drug candidate called simufilam is safe and effective in slowing down the progression of mild-to-moderate Alzheimer’s disease. Simufilam is an investigational drug candidate that has not been approved by the FDA, or any regulatory agency, for the treatment of any condition.

Clinical trials are research studies in which people volunteer to help find answers to specific health questions. When carefully conducted by doctors and nurses, clinical trials are the safest and fastest way to find new treatments and ways to improve health. For basic information about clinical trials, please visit: https://www.fda.gov/patients/clinical-trials-what-patients-need-know/basics-about-clinical-trials

Study Participation

The RethinkALZ and RefocusALZ trials are now enrolling patients!

To be considered for the RethinkALZ and RefocusALZ studies, patients must:

  • Be ages 50 to 87 years old
  • Be diagnosed with, or have a suspected clinical diagnosis of, Alzheimer’s disease
  • Have a gradual change in memory for six months or more
  • Have a family member or loved one who can be available as a study partner during the entire study
  • Be fully vaccinated for COVID-19 or have had a previous COVID-19 infection

Other criteria apply.

Study Participation

The RethinkALZ and RefocusALZ trials are now open to qualifying participants. The trials last either 52 or 76 weeks. If you enroll into one of these trials, you will receive either the oral study drug or placebo twice a day. A placebo looks like the study drug but has no impact on the person taking it. There is no cost to the patient to participate in the RethinkALZ or RefocusALZ trials or for any of the study-related procedures. No hospitalization is required. You may be compensated for your time and travel for each clinical study appointment.

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What are clinical trials?

Clinical trials are research studies in which people volunteer to help find answers to specific health questions. When carefully conducted, they are the safest and fastest way to find new treatments and ways to improve health.

Clinical trials are conducted according to a plan, called a protocol, which describes:

Volunteers who participate in a study must agree to the rules and terms outlined in the protocol. Similarly, researchers, doctors, and other health professionals who manage clinical trials must follow strict rules set by the FDA. These rules make sure that those who agree to participate are treated as safely as possible.

For many people, taking part in a clinical trial is important because their participation helps increase the understanding of disease and how to treat them. Some other benefits to participation are:

Refer A Friend

Do you know a family member or loved one who is diagnosed with Alzheimer’s disease? They may be eligible to participate in the RethinkALZ or RefocusALZ trials. Consider sharing information with them about how they can learn more.

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